Airship Entertainment (Including Girl Genius, Buck Godot, Myth Adventures, Etc. (Phil Foglio is awesome, BTW)
As We Were
Blip
By Moon Alone
Candi
Cardboard Angel
Chirault
Customers Suck!
Dead Heaven
Devil's Cake
Devil's Panties
Digger
Dominic Deegan
Down Stairs Apartment
Dreamland Chronicles
Dream*Scar
Dresden Codak
Drowtales
Earthsong Saga
Eerie Cuties
Errant Story
Evil Diva
Flipside
FreakAngels
Galaxion
Girl Genius
Girls with Slingshots
Girly
Goblins
The Guilded Age
Hanna Is Not A Boy’s Name
Jikoshia I gotta plug my best friend-rival, Em! Her comic is hilarious, epic, etc. Go read it!
Joyride
Juathuur Gatecrash
Kagerou
Kidnapped By Lesbian Pirates This comic is just so cute, innovative, and funny!

Lackadaisy Have I mentioned that this comic is awesome? Because it is. It's just awesome.
Least I Could Do
Looking for Group
Machine Flower
The Meek
Megatokyo
Menage a 3
Misfile
No Pink Ponies
Other People's Business
Penny Arcade
PETER IS THE WOLF There is an "adult" version of hte comic that adds in twenty or so pages alogn teh way that are smutty, but ironically add to the overall story.
The Phoenix Requiem
Punch and Pie
Questionable Content
Raven’s Dojo
Red Moon Rising
Red String
reMIND
Roza
Serenity Rose
Shadowgirls
Sister Claire
Skyfall
Something Positive
Sorcery 101
Spinnerette
Templar, Arizona
Three Panel Soul
Trying Human
Velharthis
Wapsi Square
The Watcher of Yaathagggu
Wayfarer's Moon
Wayward Sons
xkcd
Zap!
Zebra Girl

Web Comics which are good but *ahem* a bit perverse, or have adult content I oughta warn you about. So if you're younger than 18 it's not my fault if you click on the digital wang without my knowledge.
Collar 6
Curvy

Comics which are awesome but defunct, not updating, or complete:
Alpha-Shade
By Moon Alone
Cat Legend: Comics
Corner Alley 13
Crowfeathers
DAR
DownStairs Apartment
DREAMLESS
Geebas on Parade
Geist-Panik
Gone Astray
KIWIS BY BEAT!
Legends
MARRY ME
No Rest or the Wicked
OGHME COMICS
Penny and Aggie
Shades of Grey
Sparkling Generation Valkyrie Yuuki
Xylia